Perpetua: The UAH Journal of Undergraduate Research


College of Science


Biological Sciences


The cytotoxicity of various essential oils from plant extracts has been tested on two different breast cancer cell subtypes. An estrogen positive breast cancer, MCF7, and a triple negative breast cancer, Hs578T, were both used in this study. Concentrations (weight volume w/v) of test samples of 0.01%, 0.005%, 0.004%, 0.003% were used to determine the LC50 value for compounds determined to decrease the number of viable cells in a culture. Testing completed with MCF7 cells determined that the fraction 2C of Terminalia catappa (Teca) was the most efficient for cytotoxicity, with a percent kill of 80.56 at a concentration of 0.004% (w/v). Hs578t testing determined that fraction 3 of Ipomoea tricolor (IT) had the most efficient toxic effects, with a percent kill of 93.53 at a concentration of 0.003%(w/v), which was the lowest concentration tested.



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