College of Science
The cytotoxicity of various essential oils from plant extracts has been tested on two different breast cancer cell subtypes. An estrogen positive breast cancer, MCF7, and a triple negative breast cancer, Hs578T, were both used in this study. Concentrations (weight volume w/v) of test samples of 0.01%, 0.005%, 0.004%, 0.003% were used to determine the LC50 value for compounds determined to decrease the number of viable cells in a culture. Testing completed with MCF7 cells determined that the fraction 2C of Terminalia catappa (Teca) was the most efficient for cytotoxicity, with a percent kill of 80.56 at a concentration of 0.004% (w/v). Hs578t testing determined that fraction 3 of Ipomoea tricolor (IT) had the most efficient toxic effects, with a percent kill of 93.53 at a concentration of 0.003%(w/v), which was the lowest concentration tested.
"Cytotoxicity of Plant Extracts on MCF7 and Hs578T Breast Cancer Cell Lines,"
Perpetua: The UAH Journal of Undergraduate Research: Vol. 2:
1, Article 1.
Available at: https://louis.uah.edu/perpetua/vol2/iss1/1