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Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the deterioration of neurons that communicate via dopamine. These dopaminergic neurons undergo a phenomenon known as oxidative stress, which obstructs neuronal functioning and results in cell death. There is no treatment for PD that is highly effective in preventing neurodegeneration, so it is imperative to research its mechanisms at the molecular level. The p75 neurotrophin receptor (p75NTR) is a poorly understood protein that is involved in neurodegeneration. Oxidative stress has been shown to induce p75NTR signaling by triggering regulated proteolysis of the receptor. In the present study, we evaluated whether receptor internalization is required for oxidative stress-induced p75NTR signaling. Our results indicate that blockade of receptor internalization with dynasore prevents p75NTR proteolysis in 6-OHDA treated cells. Additionally, we evaluated the expression of coreceptors that may potentially influence p75NTR signaling in dopaminergic cells, and we determined that sortilin is present in LUHMES cells whereas TrkB and TrkC receptors are not expressed.
Research and Creative Experience for Undergraduates (RCEU)
College of Science
Darzi, Lorelei, "Characterization of p75NTR Interactors in Midbrain Dopaminergic Neurons" (2023). Summer Community of Scholars Posters (RCEU and HCR Combined Programs). 418.