Date of Award
2013
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
Committee Chair
William N. Setzer
Committee Member
Robert McFeeters
Committee Member
Luis R. Cruz-Vera
Subject(s)
Protein kinases., Phosphoinositides--Physiological effect., Cellular signal transduction.
Abstract
PI3K (phosphoinositide 3-kinase) is responsible for a large number of signaling pathways involved in a range of conditions ranging from allergic response to tumor growth. Current research is still being done to find novel selective inhibitors for the different isoforms of PI3K. This research was performed in order to find new selective inhibitors from the world of natural products. A list of known pharmaceutical inhibitors was run in order to compare how well the natural product inhibitors performed. Eleven selective and semi-selective inhibitors were found to inhibit PI3K. The alkaloids found include berberine, chelerythine, isaindigotone, noscapine, pseudocoptisine, and tetrandrine. The flavonoids found were malvidin, pentamethoxyflavone, and vitexin. The triterpenoids found to inhibit PI3K in this experiment were ganoderic acid and oleandrin. The residues that participated in binding to the ligands were examined for trends. Promising trends were found both among binding to natural products as well as pharmaceuticals.
Recommended Citation
Jackson, David, "Selective phosphoinositide 3-kinase inhibition via natural products : a computational study" (2013). Theses. 16.
https://louis.uah.edu/uah-theses/16