Date of Award
Master of Science (MS)
William N. Setzer
Tabebuia., Medicinal plants., Medical botany., Australia--Medicinal plants., Bahamas--Medicinal plants.
The phytochemical study of extracts of cytotoxic active plant species Drypetes lasiogyna and Tabebuia bahamensis species from Paluma rainforest, Northern Queensland, Australia and Abaco Island, Bahamas, respectively, has been carried out where separation, identification and characterization of chemical components were done by applying chromatographic and spectroscopic techniques. The pharmacologically active components isolated from Drypetes lasiogyna include novel compound 5α-dammar-20-ene-24,25-diol-3-yl caffeate along with 5α-dammar-20-ene-3β,24,25-triol and friedelin whereas taraxeryl acetate was extracted from Tabebuia bahamensis. 5α-Dammar-20-ene-3β,24,25-triol was shown to have good cytotoxic activity against cancer cell lines 5637, MCF-7 and MDA-MB-231 with % kill of 100%, 89.65% and 69.98%, respectively. On the other hand, dammar-20-ene-24,25-diol-3-yl caffeate exhibited good antimicrobial activity against Escherichia coli and Staphylococcus aureus. Friedelin showed mild activity against Bacillus cerus whereas taraxeryl acetate was found to possess excellent activity against Candida albicans.
Pokharel, Suraj Kumar, "Discovery of novel compound from cytotoxic active plants" (2016). Theses. 170.