Date of Award
2014
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Biological Sciences
Committee Chair
Luis R. Cruz-Vera
Committee Member
Eric Mendenhall
Committee Member
Luciano Matzkin
Subject(s)
Escherichia coli, Gene expression, Ribosomes
Abstract
In bacterial cells, ribosomes synthesize proteins by translating messenger RNAs. Newly synthesized proteins travel out of translating ribosomes through a channel named peptide exit tunnel. Nucleotides of the 23S ribosomal RNA and amino acids residues of several ribosomal proteins are in the peptide exit tunnel. Regulatory nascent peptides interact with the components of the peptide exit tunnel affecting their own synthesis. These nascent peptides interact with a narrow region of the peptide exit tunnel, which is mostly comprised of amino acid residues of the L4 r-protein. The results of this study show that the L4 ribosomal protein is important in controlling the expression of the tnaCAB tryptophanase operon in Escherichia coli.
Recommended Citation
Sharma, Prativa, "The role of the L4 ribosomal protein in the expression regulation of Escherichia coli genes" (2014). Theses. 61.
https://louis.uah.edu/uah-theses/61