Date of Award
2024
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
Committee Chair
Bernhard Vogler
Committee Member
Sharifa Love-Rutledge
Committee Member
Pamela Twigg
Subject(s)
Drug-nutrient interactions, Caffeine, Cancer--Chemotherapy, Antineoplastic agents
Abstract
Caffeine can form stacking through pi-pi interactions with aromatic anticancer drugs. While caffeine can reduce the toxicity of the anticancer drugs, caffeine can also reduce the efficacy of the anticancer drugs. Aromatic anticancer drugs, such as daunorubicin and irinotecan, work by intercalating into DNA. When caffeine binds to an anticancer drug, the new complex formed cannot easily intercalate into DNA strands. Through Nuclear Magnetic Resonance (NMR) spectroscopy, chemical shift values for pure caffeine, daunorubicin, and irinotecan, as well as, caffeine mixed with daunorubicin and irinotecan were analyzed. Different concentrations for the pure compounds and the mixtures were analyzed by NMR. The diffusion coefficients for daunorubicin, irinotecan, caffeine, and the mixtures were determined using Diffusion Ordered Spectroscopy (DOSY). This study found caffeine caused changes in chemical shift and diffusion coefficients of daunorubicin and irinotecan when mixed with caffeine due to the binding of caffeine with the anticancer drug.
Recommended Citation
Parish, Baylee, "Interactions of caffeine with anticancer drugs studied by nuclear magnetic resonance" (2024). Theses. 653.
https://louis.uah.edu/uah-theses/653